〔Abstract〕 Objective To explore the role and effectiveness of adjustable sodium ultrafiltration curve in the prevention of hypotension in hemodialysis patients. Methods From January 2018 to March 2020, a total of 120 hemodialysis patients admitted to Xiaolan People's Hospital of Zhongshan were randomly divided into control group and observation group, with 60 patients in each group. The control group received routine hemodialysis, and the observation group received adjustable sodium ultrafiltration curve dialysis. Observed and compared the changes of hemodialysis blood pressure level, clinical hemodialysis effect and dialysis dewatering volume between the two groups. Results Systolic pressure and diastolic pressure in the observation group at 2 h and the end of dialysis were higher than those in the control group at the same time, the differences were statistically significant (P < 0.05). The total effective rate of dialysis in the observation group was higher than that in the control group, the difference was statistically significant (P < 0.05). The actual dewatering amount of dialysis of the observation group was greater than that of the control group (P < 0.05). Conclusion The application of the adjustable sodium ultrafiltration curve model in the prevention of hypotension in hemodialysis patients can effectively regulate the blood pressure level of patients, thereby expanding blood volume, improve dehydration.