〔Abstract〕 Objective To analyze the clinical efficacy and safety of digestive endoscopy in the treatment of acute non-varicose upper gastrointestinal bleeding (ANVUGIB). Methods A total of 80 ANVUGIB patients admitted to Loudi Central Hospital from January 2019 to December 2020 were selected and randomly divided into conservative group and endoscopic group with 40 patients in each group. The conservative group was treated with conventional drug therapy, and the endoscopic group was treated with digestive endoscopy on the basis of conventional drug therapy. The time of hemorrhage occlusion, length of hospital stay, hemoglobin level, oxygen saturation level, oxygen partial pressure level, acute physiology and chronic health score, total treatment response rate, incidence of rebleeding and adverse reactions were compared between the two groups. Results The bleeding blocking time and hospital stay in the endoscopic group were shorter than those in the conservative group, the differences were statistically significant (P < 0.05). After treatment, the level of hemoglobin, oxygen saturation and oxygen partial pressure (PaO2) in the endoscopic group were higher than those in the conservative group, and the acute physiological and chronic health scores were significantly lower than those in the conservative group, with statistical significance (P < 0.05). The total effective rate of the endoscopic group was 100.00 %, higher than 80.00 % of the conservative group, the difference was statistically significant (P < 0.05). The incidence of rebleeding in the endoscopic group was 0.00%, lower than 17.50% in the conservative group, and the difference was statistically significant (P < 0.05). No adverse reactions occurred in the two groups. Conclusion The clinical effect of digestive endoscopy in the treatment of ANVUGIB is definite, which can accelerate the blocking of bleeding, maintain the health of patients, and reduce the phenomenon of rebleeding, with high safety.