〔Abstract〕 Objective To study the effect of emergency blood purification treatment in patients with severe aconitine poisoning and its influence on prognosis. Methods From March 2018 to May 2020, 56 patients with severe aconitine poisoning who were treated in the emergency department of Changsha Hospital of Traditional Chinese Medicine were selected as the research objects. According to the random number table model, there were 28 cases in the control group and 28 cases in the observation group. The control group received routine emergency treatment, and the observation group received blood purification treatment based on the treatment conditions of the control group. The two groups were compared with indicators such as emergency treatment efficacy, cardioversion time of arrhythmia, hospital stay and rate of adverse reactions. Results The total effective rate of treatment for patients in the observation group was 96.43%, which was significantly higher than 75.00% in the control group, the difference was statistically significant (P < 0.05). The cardioversion time and hospitalization time of patients in the observation group were significantly shorter than those in the control group, with statistical significances (P < 0.05). The total incidence of adverse reactions in observation group was 3.57%, which was significantly lower than 21.43% in control group (P < 0.05). There was no death in the observation group and 10.71% mortality in the control group, and there was no significant difference in mortality between the two groups (P > 0.05). Conclusion Emergency blood purification treatment for patients with severe aconitine poisoning can enhance the clinical treatment effect and and improve the prognosis of patients.