〔Abstract〕 Objective To investigate the clinical effect of genetic recombined bovine basic fibroblast growth factor (rbFGF) in promoting burn wound healing. Methods 60 burn patients admitted to Central People's Hospital of Zhanjiang from July 2019 to April 2021 were selected as the research objects. According to the random number table method, they were divided into observation group and control group, with 30 cases in each group.The control group received external application of sterile Vaseline gauze after debridement, and the observation group received rbFGF after debridement. The healing rate, total healing time, superficial second degree wound healing time, and deep second degree wound healing time after 1 week, 2 weeks, and 3 weeks were observed the total effective rate after 3 weeks of treatment was also observed. Results Compared with the control group, the healing rate of the observation group at 1 week, 2 weeks and 3 weeks and the total effective rate after 3 weeks were significantly higher, and the total healing time, shallow second degree wound healing time and deep second degree wound healing time were significantly shorter in the observation group, the differences were all statistically significant (P < 0.05). Conclusion rbFGF has a good effect on promoting burn wound healing.