〔Abstract〕 Objective To investigate the effect of verapamil combined with intra-arterial infusion of nitroglycerin in the treatment of cerebral vasospasm during neurointerventional therapy. Methods From January 2020 to April 2021, 23 patients who received neurointerventional therapy (emergency + elective) at Dongguan Binhaiwan Central Hospital and had vasospasm during the operation were selected and randomly divided into control group (11 cases) and observation group (12 cases). The observation group was treated with verapamil combined with nitroglycerin perfusion, and the control group was treated with papaverine perfusion. The differences in the time and degree of vasospasm relief between the two groups were observed, and the safety of verapamil combined with nitroglycerin was evaluated. Results The remission rate of vasospasm in the observation group was 83.3% within 5 minutes, which was significantly higher than 27.3% in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in vital signs before and after treatment in the two groups (P > 0.05). Conclusion The method of intra-arterial infusion of verapamil combined with nitroglycerin can quickly and effectively relieve cerebral vasospasm, shorten the operation time, and has advantages in quality control of the operation time node. This method was quickly effective, long-lasting and stable as well as highly safe in relieving vasospasm.