〔Abstract〕 Objective To study the effect of ornidazole mixture assisted filling in the treatment of dental pulp disease. Methods 68 patients with endodontic disease admitted to the First Affiliated Hospital of Zhengzhou University from May 2018 to May 2019 were selected and randomly divided into control group and observation group, with 34 cases in each groups. Among them, the control group was treated with routine filling treatment, and the observation group was treated with ornidazole mixture adjuvant filling treatment. The therapeutic effects of the two groups were compared. Results The total effective rate of the observation group was 97.06%, which was higher than 82.35% of the control group, the difference was statistically significant (P < 0.05). The adverse reaction rate of the observation group was 5.88%, lower than 17.65% in the control group, the difference was statistically significant (P < 0.05). Conclusion Ornidazole mixture assisted filling is effective in the treatment of dental pulp diseases, which can significantly improve the treatment efficiency and reduce the incidence of adverse reactions.