〔Abstract〕 Objective To observe the effects of different antivenoms on the coagulation function of trimeresurus stejnegeri bite. Methods A total of 50 patients with snakebite of trimeresurus stejnegeri treated in the Second Hospital of Longyan from September 2017 to November 2020 were selected and randomly divided into group A and group B, with 25 cases in each group. Group A was given agkistrodon acutus antivenin, group B was given agkistrodon hyalys antivenin. The changes of coagulation function indexes in the two groups were observed, and the diagnosis and treatment process and effects were analyzed. Results The average recovery time of coagulation function in group A was (3.68 ± 1.41) d, shorter than that in group B (5.56 ± 2.26) d, and the difference was statistically significant (P < 0.05). On the 2nd and 4th day after treatment, PT, APTT and TT levels in group A were lower than those in group B, while Fib was higher than that in group B, with statistical significance (P < 0.05). Conclusion In the treatment of trimeresurus stejnegeri bite patients, agkistrodon acutus antivenin has a better effect, compared with agkistrodon halys antivenin, can better improve the coagulation function of patients with abnormal conditions, shorten the treatment time, promote patients to recover as soon as possible.