〔Abstract〕 Objective To evaluate the clinical value of 64 slice computed tomography (CT) in the diagnosis of solitary pulmonary nodules. Methods 150 patients with solitary pulmonary nodules treated in Ganjingzi District People's Hospital of Dalian from March 2018 to June 2020 were selected. According to the severity of the disease, patients with malignant nodules (106 cases) were regarded as lung adenocarcinoma group and patients with benign nodules (44 cases) were regarded as benign nodules group. The differences of CT manifestations and enhancement methods between the two groups were compared. Results Compared with the benigns nodule group, the lesion morphology, tumor-pulmonary interface, marginal condition and internal components in the CT scan signs of the lung adenocarcinoma group were statistically significant (P < 0.05). There was no significant difference in bronchial truncation sign and cavity sign between the two groups (P > 0.05). In the lung adenocarcinoma group, the proportions of arterial stage light-to-moderate enhancement and venous stage delayed enhancement were higher than those of the benign nodule group, the arterial stage was significantly enhanced and the venous stage enhancement was significantly lower than that of the benign nodule group (P <0.05). Conclusion 64 slice CT is effective for solitary pulmonary nodules. The combination of characteristic manifestations and enhanced features is helpful to improve the diagnostic accuracy.