〔Abstract〕 Objective To study the clinical significance of serum hypersensitive C–reactive protein (hs-CRP) and homocysteine (Hcy) in patients with pregnancy-induced hypertension syndrome. Methods 112 patients with gestational hypertension syndrome treated in Xinyang Central Hospital from May 2018 to January 2020 (observation group) and 98 healthy pregnant women who underwent outpatient physical examination during the same period (control group) were selected as the research objects, and the serum hs-CRP and Hcy levels of pregnant women in the two groups were compared. Logistic regression analysis was performed to determine whether the two factors were the influencing factors of gestational hypertension syndrome. Results The serum hs-CRP and Hcy levels in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). In the observation group, the levels of serum hs-CRP and Hcy in patients with different degrees of gestational hypertension syndrome showed a gradually increasing trend with the aggravation of the disease, and the differences between the two groups were statistically significant (P < 0.05). Serum hs-CRP and Hcy levels are independent risk factors for gestational hypertension syndrome. Conclusion Serum hs-CRP and Hcy levels have high clinical value in the diagnosis of gestational hypertension syndrome, both of which are sensitive indicators of gestational hypertension syndrome.