〔Abstract〕 Objective To explore the effects of Guizhi Fuling pill and Shenqi Pill on collateral circulation and clinical efficacy of acute ischemic stroke with kidney deficiency and blood stasis. Methods 60 patients with acute ischemic stroke of kidney deficiency and blood stasis type treated in Jiangmen Wuyi Hospital of Traditional Chinese Medicine from October 2018 to may 2020 were randomly divided into observation group and control group, with 30 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Guizhi Fuling pill and Shenqi Pill on the basis of the control group. The collateral circulation, nerve defect and living ability of the two groups were compared. Results There was no significant difference in pulsation index (PI) and resistance index (RI) between the two groups before treatment (P > 0.05). After treatment, the PI and RI of the two groups decreased to varying degrees, and these indexes of the observation group were lower than those of the control group (P < 0.05); There was no significant difference in NIHSS score between the two groups before treatment (P > 0.05). After treatment, NIHSS score of the two groups decreased in varying degrees, and NIHSS score the observation group was lower than that of the control group, the difference was statistically significant (P < 0.05); There was no significant difference in the scores of Barthel index (BI) and modified Rankin revised scale (mRS) between the two groups before treatment (P > 0.05). After treatment, the BI score of the two groups increased in varying degrees, and the mRS score decreased in varying degrees. The BI score of the observation group was higher than that of the control group, and the mRS score was lower than that of the control group (P < 0.05). Conclusion Guizhi Fuling pill and Shenqi Pill are effective in patients with acute ischemic stroke of kidney deficiency and blood stasis type. They can improve collateral circulation, reduce nerve defect, and improve living ability.