〔Abstract〕 Objective To explore the clinical effects of acupuncture and moxibustion in the treatment of insomnia. Methods 62 patients with insomnia who were treated in Zhuzhou Central Hospital from January 2019 to June 2020 were selected as the research objects.They were divided into observation group (31 cases) and control group (31 cases) by lottery method. The control group was treated with conventional drugs, and the observation group was treated with acupuncture and moxibustion on the basis of conventional drug treatments. The treatment effects and sleep quality scores of the two groups were observed. Results The total effective rate of treatment in the observation group was 96.77%, which was significantly higher than 74.19% in the control group (P < 0.05). Before treatment, there was no significant difference in sleep quality between the two groups (P > 0.05). After treatment, the scores of hypnotics, sleep disorders, sleep efficiency, sleep time, and time to fall asleep in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Acupuncture and moxibustion can effectively improve the sleep quality of patients with insomnia and has clinical value.