〔Abstract〕 Objective To investigate the effect of early acupuncture and moxibustion on hemiplegia after acute cerebral infarction. Methods 100 patients with hemiplegia treated in Guangzhou Xinhai Hospital from February 2018 to April 2019 were selected as the research object. They were randomly divided into observation group and control group, with 50 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with early acupuncture and moxibustion on the basis of the control group. The motor function, quality of life score and treatment efficiency of the two groups were compared. Results Before treatment, there was no significant difference in motor function scores between two groups (P > 0.05); After treatment, the motor function scores of upper and lower limbs in the observation group were significantly higher than those in the control group (P < 0.05). After treatment, the scores of quality of life in the observation group were significantly higher than those in the control group (P < 0.05). The total effective rate of the observation group was 98.00%, which was higher than 84.00% of the control group (P < 0.05). Conclusion Early acupuncture has a good effect on hemiplegia after acute cerebral infarction, which can effectively improve the symptoms and improve the living standard of patients.