〔Abstract〕 Objective To investigate the effect of continuous subcutaneous insulin infusion in pregnant women with gestational diabetes mellitus. Methods 84 pregnant women with gestational diabetes admitted in Jiamusi Central Hospital from January 2017 to January 2019 were selected and randomly divided into control group and observation group, with 42 cases in each group. The control group was treated with multiple subcutaneous injections of insulin, and the observation group was treated with continuous subcutaneous infusion of insulin. The blood glucose level, treatment and pregnancy outcome of the two groups were compared. ResultsAfter treatment, the 2 h postprandial blood glucose (6.95 ± 0.43) mmol·L-1 and fasting blood glucose (5.73± 0.58) mmol·L-1 of the pregnant women in the observation group were lower than those of the control group (7.32 ± 0.64) mmol·L-1, (6.09 ± 0.65) mmol·L-1, the differences were statistically significant (P < 0.05); The observation group's maternal blood glucose standard time (6.74 ± 2.46) d, hospitalization time (8.96 ± 2.46) d were shorter than the control groups, (8.17 ± 2.09) d, (10.62 ± 2.37) d, insulin dosage (39.48 ± 3.36) U·d-1 is lower than (41.53 ± 2.17) U·d-1 of the control group, the differences were statistically significant (P < 0.05); maternal hypoglycemia (7.14%), premature delivery (4.76%), and cesarean section rate (19.05%) in the observation group were lower than those in the control group (26.19%, 21.43%, 42.86%), and the differences were statistically significant (P < 0.05). Conclusion Continuous subcutaneous insulin infusion in the treatment of gestational diabetes mellitus can effectively improve the blood glucose control effect, reduce the dosage of insulin, promote the recovery of the pregnant women as soon as possible, and improve the pregnancy outcome.