〔Abstract〕 Objective To explore the related factors of iron deficiency anemia in the middle and late pregnancy. Methods 121 pregnant women with iron deficiency anemia in the middle and late pregnancy admitted to Xiamen Fifth Hospital from January 2019 to June 2020 were retrospectively selected as the anemia group, and 100 normal pregnant women in our hospital during the same period were selected as the non-anemia group. The clinical data of pregnant women in the two groups were collected and reviewed to analyze the related factors of iron deficiency anemia in the middle and late pregnancy. Results Multivariate logistic regression analysis showed that, Age > 35 years old, menarche age ≤ 13 years old, parturient women, education level of primary school or below, living in rural areas, family income < 3000 yuan per month, poor eating habits, chronic intestinal diseases, living in newly renovated houses, number of abortions ≥ 3, menstruation before pregnancy > 100 mL·sub-1 were the rick factors for iron deficiency anemia (P < 0.05). Conclusion There are many factors related to iron deficiency anemia in pregnant women in the middle and late trimester of pregnancy, and corresponding intervention measures should be formulated according to their risk factors to reduce the incidence of iron deficiency anemia.