〔Abstract〕 Objective To study the clinical effect of neck anastomosis with tubular gastroesophageal new triangular end-toend instrument in the operation of esophageal cancer. Methods 50 patients with esophageal cancer treated in the First Affiliated Hospital of Gannan Medical College from January 2015 to February 2020 were divided into two groups according to the single and even numbers of admission order. 25 patients in the odd number were treated with tubular anastomosis in the control group and 25 patients in the even number were treated with tubular gastroesophageal new triangle end-to-end instrument neck anastomosis in the observation group. The therapeutic effects of the two groups were compared. Results The time of esophagogastric anastomosis in the observation group was shorter than that in the control group, the length of gastric dissociation was longer than that in the control group, the operation time was shorter than that in the control group, and the hospital stay was shorter than that in the control group; the differences were all statistically significant (P < 0.05); The incidence of postoperative complications in the observation group was 16.00%, lower than 44.00% in the control group with statistically significant difference (P < 0.05). Conclusion The application of tubular gastroesophageal new triangular end-to-end instrument neck anastomosis in the operation of esophageal cancer can reduce the occurrence of postoperative anastomotic leakage and anastomotic stenosis, and shorten the postoperative hospital stay.