〔Abstract〕 Objective To explore the effects of intraspinal anesthesia analgesia on delivery outcome and neonatal prognosis. Methods A total of 200 parturients who delivered in Wuchuan Maternal and Child Health Care Family Planning Service Center from March 2018 to December 2019 were selected as the research object, and divided into observation group and control group according to maternal wishes with 100 cases in each group. The control group was given routine natural delivery, and the observation group was given spinal block anesthesia for labor analgesia during natural delivery. The indicators of analgesic effect, delivery situation and Apgar score were compared between the two groups. Results The VAS scores in the observation group were significantly lower than that in the control group at 5 min, 30 min and 60 min of the first labor stage (P < 0.05). The incidence of natural delivery in the observation group (196 cases, 98.00%) was significantly higher than that in the control group (186 cases, 93.00%) (P < 0.05). The first stages of labor and the second stages of labor in the observation group were significantly lower than those in the control group (P < 0.05). The Apgar scores at 1 min and 5 min after birth in observation group were significantly higher than those in the control group (P < 0.05). Conclusion Intraspinal block anesthesia had remarkable analgesic effect in natural delivery, which is beneficial to improve delivery outcome and newborn prognosis.