〔Abstract〕Objective To explore the efficacy of cyclophosphamide combined with glucocorticoid in the treatment of nonspecific cerebral arteritis obliterans. Methods 163 cases of non-specific cerebral arteritis obliterans treated in Fukuang General Hospital of Liaoning Health Industry Group from January 2018 to December 2019 were selected and divided into single group and combination group, with 82 patients in single group and 81 patients in combination group. The single group was treated with glucocorticoids, and the combination group was treated with cyclophosphamide combined with glucocorticoids. The incidence of adverse reactions, inflammatory response factors, oxygen free radicals and the effective rate of treatment were observed and compared between the two groups. Results The adverse reaction rate of patients in the combination group was 18.52%, which was significantly lower than 39.02% in the single group, and the difference was statistically significant (P < 0.05). The treatment effective rate of patients in the combination group was 69.14%, which was significantly higher than 52.44% in the single group, the difference was statistically significant (P < 0.05); the intercellular adhesion molecule-1 (ICAM-1), myeloperoxidase (MPO), superoxide dismutase (SOD), malondialdehyde (MDA) and other inflammatory response factors and oxygen free radical levels in the combination group were better than the single group, the difference was statistically significant (P < 0.05). Conclusion In the treatment of non-specific occlusive cerebral arteritis, the application of cyclophosphamide combined with glucocorticoids can reduce adverse reactions, improve curative effects, and reduce the level of cerebrovascular inflammatory factors.