〔Abstract〕Objective To analyze the intervention effect of amiodarone combined with resistance training in patients with acute myocardial infarction and ventricular arrhythmia. Methods A total of 86 patients with acute myocardial infarction and ventricular arrhythmia admitted to Jiamusi Central Hospital from January 2018 to December 2019 were selected. According to different treatment methods, all patients were divided into observation group and control group. with 42 cases in each group. The control group was treated with amiodarone, and the observation group was treated with amiodarone combined with resistance training. The heart function and 6-min walk test of the two groups before and after treatment were observed and compared. Results Before treatment, there was no statistically significant difference in the levels of left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDD) and cardiac output (CO) between the two groups of patients (P > 0.05); After treatment, the LVEF and CO of the observation group were higher than those of the control group, and the LVEDD was lower than that of the control group. The difference was statistically significant (P < 0.05). The 6 min test distance comparison between the two groups before treatment was not statistically significant (P > 0.05); After treatment, the 6-min walk test distance of the observation group was longer than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion In patients with acute myocardial infarction and ventricular arrhythmia, application of amiodarone combined with resistance training can promote the recovery of their cardiac function, improve their activity endurance, and further promote their physical recovery.