〔Abstract〕 Objective To explore the diagnostic value of immunoglobulin combined with liver function testing for liver failure. Methods A total of 46 patients with liver failure diagnosed and treated in Guangzhou Development Zone Hospital from June 2017 to December 2019 were selected as the observation group, and 40 healthy patients who underwent normal physical examination during the same period were selected as the control group. Both immunoglobulin and liver function tests were performed, and the two groups of immunoglobulin and liver function indexes were observed and compared. Results The levels of immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The levels of γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Timely detection of immunoglobulin and liver function in patients with liver failure can provide effective guidance for clinical diagnosis and treatment, and has high value in evaluating the prognosis of patients