〔Abstract〕 Objective To study the therapeutic effect of ulinastatin combined with low-molecular-weight heparin calcium on emergency severe sepsis. Methods 64 emergency severe sepsis patients admitted to the Second People's Hospital of Jiaozuo City from October 2018 to October 2019 were selected and divided into a control group (32 cases) and an observation group (32 cases), according to the order of admission . The control group was treated with ulinastatin, and the observation group was treated with ulinastatin combined with low-molecular-weight heparin calcium. After treatment, the rates of new infections between the two groups were compared. Detect the inflammatory factor indexes before and after treatment in the two groups of patients such as procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), venous blood platelet count (PLT), plasma Prothrombin time (PT) and activated partial thromboplastin time (APTT)] all of these indexes were compared between the two groups. Results The rate of new infections in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, there were significant differences in the levels of inflammatory factors and coagulation indicators between the two groups of patients. The indicators in the observation group were better than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion For emergency patients with severe sepsis, treatment with ulinastatin combined with low-molecular-weight heparin calcium can improve their condition, reduce the risk of bacterial infection, improve blood coagulation indicators, and have anti-inflammatory effects.