〔Abstract〕 Objective To explore the clinical effects of enteral nutrition therapy technology applied to patients with severe acute pancreatitis (SAP). Methods A total of 60 SAP patients admitted to Zhumadian Central Hospital from June 2017 to November 2019 were selected and divided into a control group and an observation group with 30 cases in each group, according to the random number table method. The control group was given complete parenteral nutrition support treatment, and the observation group was given enteral nutrition support treatment for 1 month. The levels of inflammatory factors, acute physiology and chronic health score Ⅱ (APACHE Ⅱ) and nutritional indicators of the two groups of patients were observed. Results Compared with before treatment, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels were all decreased in the two groups after treatment, and the differences were statistically significant (P < 0.05) ), and the serum CRP level of the observation group was lower than that of the control group, the difference was statistically significant (P < 0.05). Before treatment, there was no statistically significant difference in APACHE Ⅱ between the control group and the observation group (P > 0.05); after treatment, the APACHE Ⅱ of the observation group was lower than the control group, and the difference was statistically significant (P < 0.05). Compared with before treatment, the levels of ALB and Hb of the two groups of patients were significantly increased after treatment, and the blood amylase levels were significantly reduced, and the differences were statistically significant (P < 0.05); after treatment, the ALB level of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). There was no statistically significant difference in Hb and blood amylase levels between the observation group and the control group after treatment (P > 0.05). Conclusion Enteral nutrition therapy can reduce the levels of inflammatory factors and APACHE Ⅱ in SAP patients, improve the nutritional status of patients, and help patients recover.