〔Abstract〕 Objective To explore the effect of concentrated growth factor (CGF) combined with guided tissue regeneration (GTR) in the treatment of teeth with severe periodontal disease. Methods Fifty-one patients with severe periodontal disease admitted to the Affiliated Stomatological Hospital of Xiamen Medical University from January 2019 to May 2020 were randomly divided into control group (25 cases) and observation group (26 cases). The control group was treated with GTR, while the observation group was treated with CGF on the basis of the control group. Periodontal condition, inflammatory factor level and complication rate of the two groups were observed. Results After the operation (after one year of follow-up), the sulcus bleeding index (SBI), clinical attachment loss (CAL) and periodontal probing depth (PD) of the two groups were all smaller than those before treatment, and the observation group was smaller than that of the control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the two groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group, with statistical significance (P < 0.05). The incidence of complications in observation group (15.38%) was significantly lower than that in control group (40.00%), and the difference was statistically significant (P < 0.05). Conclusion CGF combined with GTR can reduce inflammation and promote periodontal recovery, and the incidence of complications is lower