〔Abstract〕 Objective To explore the effect and value of aminophylline combined with papaverine in amniotic fluid embolization. Methods 62 patients with amniotic fluid embolism treated in Wancheng maternal and Child Health Hospital of Nanyang city from August 2014 to August 2019 were divided into two groups according to the order of admission. The observation group (32 cases) was treated with aminophylline combined with papaverine, and the control group (32 cases) was only treated with papaverine. The total effective rates symptom score and incidence of adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 96.88%, which was higher than 81.25% of the control group (P < 0.05); There was no significant difference in the total score of symptoms between the two groups before treatment (P > 0.05). After 4 weeks, 8 weeks and at the end of the course of treatment, the symptom scores of the observation group were lower than those of the control group (P < 0.05); The incidence of adverse reactions in the observation group was 15.63%, compared with 18.75% in the control group, the difference was not statistically significant (P > 0.05). Conclusion Aminophylline combined with papaverine can achieve ideal effect in the treatment of amniotic fluid embolism, with no serious adverse reactions and high safety