〔Abstract〕 Objective To investigate the effect of sufentanil on intravenous postoperative analgesia and clinical anesthesia, so as to provide reference for the best medication plan for clinical anesthesia. Methods A total of 100 patients who underwent general anesthesia in the People's Hospital of Huiji District, Zhengzhou City from January 2017 to December 2018 were selected as the research objects. The study was divided into groups according to the order of admission. The first 50 patients were admitted as the control group and clinical anesthesia and postoperative analgesia were performed by using sufentanil, and 50 cases after admission were set as the observation group. and sufentanil was selected for clinical anesthesia and postoperative analgesia, and the effects of clinical anesthesia and analgesia between the two groups were compared. Results Compared with the control group, the visual analogue scoring (VAS) score of the observation group was not statistically different (P > 0.05); the time to wake up and the time to regain spontaneous breathing in the observation group were shorter than those of the control group, and the differences were both statistically significant (P < 0.05); the incidence of postoperative adverse reactions in the observation group (4%) was lower than that in the control group (16%), and the difference was statistically significant (P < 0.05). Conclusion Sufentanil is more effective for intravenous postoperative analgesia and clinical anesthesia. It can achieve anesthesia effect equivalent to fentanyl, with fewer adverse reactions and higher safety.