〔Abstract〕 Objective To explore the safety of laparoscopic-assisted radical resection of colon cancer for patients with colon cancer. Methods A total of 78 patients with colon cancer who underwent surgical treatment from Shimen County Maternal and Child Health Family Planning Service Center from March 2018 to April 2020 were randomly divided into control group and observation group, with 39 cases in each group. The observation group was treated with laparoscopic-assisted radical resection of colon cancer, and the control group was treated with open radical resection of colon cancer. To observe and compare the length of time for the anus to recover after the operation, the length of time to eat a liquid diet after the operation, and the incidence of postoperative complications. The total amount of blood loss during the operation, the length of operation, the length of getting out of bed, the length of hospitalization, and the percentage of overall satisfaction with the surgical treatment. Results The length of time for the observation group to recover from the anus and the length of time to eat a liquid diet after the operation were both shorter than those of the control group (P < 0.05). The postoperative complication rate of the observation group was 2.56%, which was lower than 15.38% of the control group, the difference was statistically significant (P < 0.05). The total blood loss, the length of operation, the length of walking out of bed, and the length of stay in the observation group were all better than those of the control group, and the differences were statistically significant (P < 0.05); 36 cases (92.31%) in the observation group were satisfied with the operation, which was better than 29 cases in the control group (74.36%), the difference was statistically significant (P < 0.05). Conclusion Laparoscopic-assisted radical resection of colon cancer for colon cancer patients shows good surgical safety