〔Abstract〕 Objective To analyze the application effect of anti-tuberculosis plate drugs in the treatment of pulmonary tuberculosis and the occurrence of adverse reactions. Methods A total of 70 pulmonary tuberculosis patients admitted to Hanshou County People's Hospital from February 2018 to February 2020 were selected and randomly divided into control group and observation group, with 35 cases in each group. The observation group was treated with anti-tuberculosis plate combination drugs, and the control group was treated with conventional treatment methods. The treatment effect and the incidence of adverse reactions were observed and compared between the two groups. Results The total effective rate of treatment in the observation group was 97.14%, which was higher than 74.29% in the control group. The difference was statistically significant (P < 0.05); the adverse reaction rate in the observation group was 8.57%, which was lower than that in the control group. 28.57%, the difference was statistically significant (P < 0.05). Conclusion The application effect of anti-tuberculosis plate drugs in the treatment of pulmonary tuberculosis patients is significant, the incidence of adverse reactions is lower, the safety is high, and the clinical application value is higher.