〔Abstract〕 Objective To observe the effect of selenium yeast combined with levothyroxine sodium on hypothyroidism. Methods 54 patients with hypothyroidism admitted to the Yellow River Central Hospital from November 2018 to November 2019 were selected as the research objects, and the patients were divided into a control group (27 cases: single levothyroxine sodium treatment) and Observation group (27 cases: selenium yeast combined with levothyroxine sodium treatment), compare the treatment effect of the two groups of patients. Results After 3 courses of treatment, the levels of thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in the observation group were lower than those in the control group, and the total effective rate of treatment in the observation group was higher than that in the control group. The differences were statistically significant. Academic significance (P < 0.05). Conclusion The therapeutic effect of selenium yeast combined with levothyroxine sodium in patients with hypothyroidism is significantly better than that of single levothyroxine sodium.