〔Abstract〕 Objective To observe the curative effect of interventional therapy for middle and advanced primary liver cancer and the influence of alanine aminotransferase, serum alpha and fetal protein, and serum total bilirubin, to collect clinical data and analyze them to lay a theoretical basis for subsequent clinical treatment. Methods 100 patients with primary liver cancer admitted to Luoyang Hospital from November 2017 to November 2019 were selected, randomly divided into observation and control groups, with 50 cases each.The control group underwent conventional hepatic arterial chemoembolization (TACE) treatment and the observed group injected anhydrous ethanol on a control basis with percutaneous hepatocentesis. Changes in total tumor control efficiency, survival and alanine amino transferase (ALT), serum methyl fetal protein (AFP), and total bilirubin (TBIL) were observed in the two groups of patients. Results AFP, ALT, TBIL comparison between the two groups (P > 0.05); After treatment, the observed group were lower than the control group, which was statistically significant (P < 0.05).The total treatment efficiency of the patients in the observation group was 84.00%, significantly higher than 70.00% in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in survival between the two groups at 6 months of follow-up (P > 0.05); the survival rate of patients in the observation group were at 12,18 and 24 months over time was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Interventional therapy for medium and advanced primary liver cancer can help patients effectively reduce ALT, AFP, TBIL and improve efficacy and survival.