〔Abstract〕 Objective To explore and analyze the effect of low-position water sac induced labor combined with epidural labor analgesia in parturients. Methods 135 primiparas who gave birth from January 2020 to December 2020 in Xinghua People's Hospital were selected. According to the different Methods of delivery intervention, they were divided into 85 cases in the control group and 50 cases in the observation group. The control group was delivered with epidural analgesia, and the observation group was delivered with low-position water sac combined with epidural analgesia. The two groups were compared with the mothers’ labor duration, 24 hours postpartum bleeding, transition to cesarean section rate, neonatal outcome and complication rate. Results The first stage of labor and total labor time of the observation group were shorter than those of the control group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference in the time of the second stage of labor, the third stage of labor, and the amount of bleeding after 24 hours between the two groups (P > 0.05); the transition rate of cesarean section in the observation group was 4.0% (2/50), which was low compared with 10.6% (9/85) of the control group, the difference was statistically significant (P < 0.05); the comparison of Apgar scores and newborn weights of newborns at 1 and 5 minutes of birth between the two groups was not statistically significant (P > 0.05); There was no statistically significant difference in the incidence of complications between the two groups of parturients (P > 0.05). Conclusion The application of low-position water sac induction combined with epidural analgesia in parturient women has a definite effect. It can relieve the pain of the parturient and improve the vaginal delivery rate while shortening the labor. It is a safe method and does not affect the outcome of the mother and baby. It has high clinical application value.