〔Abstract〕 Objective To analyze and study the efficacy of indobufen combined with clopidogrel in the treatment of acute ischemic stroke. Methods A total of 68 patients with acute ischemic stroke admitted to Puning People's Hospital from December 2018 to December 2020 were selected. According to different treatment Methods, they were divided into control group and observation group, each with 34 cases. The observation group was treated with indobufen combined with clopidogrel, and the control group was treated with aspirin combined with clopidogrel. The treatment effect, the National Institutes of Health Stroke Scale (NIHSS), Barthel index, and the incidence of adverse reactions were compared between the two groups of patients. Results The total effective rate of treatment in the observation group was 97.06%, which was higher than 79.41% in the control group. The difference was statistically significant (P < 0.05). After treatment, the NIHSS score of the observation group was lower than that of the control group, and the Barthel index was higher than that of the control group. Group, the difference was statistically significant (P < 0.05); the incidence of adverse reactions in the observation group was 2.94%, which was lower than 14.71% in the control group, and the difference was statistically significant (P < 0.05). Conclusion Indobufen combined with clopidogrel in the treatment of acute ischemic stroke has the effect of reducing the degree of neurological deficits and imp