〔Abstract〕 Objective To observe the effects of Shenmai injection combined with metoprolol tartrate injection on cardiac function and neuroendocrine factors in patients with dilated cardiomyopathy. Methods 80 patients with dilated cardiomyopathy treated in Ruzhou first people's Hospital from January 2017 to January 2018 were selected for study. According to the method of drawing lots, they were divided into 40 cases in the observation group and 40 cases in the control group. The control group was treated with metoprolol tartrate injection, and the observation group was treated with Shenmai injection combined with metoprolol tartrate injection. The clinical effects of the two groups were compared. Results Before treatment, there was no significant difference in left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD) and left ventricular end diastolic diameter (LVEDd) between the two groups (P > 0.05); after treatment, LVEF in the observation group was higher than that in the control group, and LVESD and LVEDd in the observation group were lower than those in the control group (P < 0.05). Before treatment, there was no significant difference in the levels of neuroendocrine factors between the two groups (P > 0.05); after treatment, the levels of neuroendocrine factors in the observation group were lower than those in the control group (P < 0.05). Conclusion Shenmai injection combined with metoprolol tartrate injection can significantly improve the cardiac function and the level of neuroendocrine factors in patients with dilated cardiomyopathy