〔Abstract〕 Objective To investigate and analyze the effect of brachial plexus block assisted by intubation general anesthesia in pediatric upper limb surgery. Methods A total of 80 children admitted to Dongguan Hospital of Traditional Chinese Medicine for upper limb surgery from January 2018 to December 2019 were included in this study and divided into control group and study group by envelope method, with 40 cases in each group. The control group was given intubation general anesthesia, and the study group was given intubation general anesthesia assisted brachial plexus block. The mean arterial pressure (MAP) and heart rate (HR) levels, recovery time, postoperative pain and adverse reactions were compared between the two groups. Results There were no significant differences in MAP and HR levels between the two groups at T0 (P > 0.05). MAP and HR levels were increased in both groups at T1 and T2, and the levels of these indicators in the study group were lower than those in the control group, with statistical significance (P < 0.05). The awakening time of the children in the study group was shorter than that in the control group, and the postoperative pain score was lower than that in the control group, with statistically significant differences (P < 0.05). The incidence of drowsiness and agitation during extubation in the study group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Brachial plexus block assisted by intubation general anesthesia in children's upper limb surgery has ideal application effect, which can effectively maintain the stability of children's circulatory system, with low postoperative pain, good recovery quality and low incidence of adverse reactions.