〔Abstract〕 Objective To investigate the clinical effect of external fixation and internal fixation for traumatic fracture of extremities. Methods 90 patients with traumatic limb fracture were randomly selected from the First Hospital of Sanming City from April 2019 to April 2020. The observation group was treated with external fixation, while the control group was treated with internal fixation. The curative effect of the two groups was compared. Results the Observation Group patients operation time, hospitalization time shorter than the control group, less bleeding, visual analogue scale (VAS) score lower than the control group, the differences were statistically significant (P < 0.05) . After treatment, the levels of C-reactive protein (CPR) and norepinephrine (IVE) in the two groups were lower than those before treatment, and the levels of NE and CRP in the observation group were lower than those in the control group(P < 0.05) . The incidence of complication of the observation group was 2.22% , which was lower than that of the control group (17.78%) (P < 0.05). Conclusion External Fixation for the treatment of traumatic fracture of limbs is characterized by short operation time, less pain, less complications and rapid recovery, and can reduce inflammatory stress reaction.