〔Abstract〕 Objective To study the application and effect of modified blind insertion of nasoenteric tube in critically ill patients. Methods A total of 200 critically ill patients admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to January 2020 were selected as the research objects, and they were randomly divided into two groups, with 100 cases in the control group and 100 cases in the observation group. Among them, the observation group was clinically placed with improved blind insertion technology, while the control group was placed with conventional blind insertion technology, and the application effects of the two groups were compared. Results The one-time success rate of intubation in the observation group was 87.0 %, higher than 59.0 % in the control group, and the incidence of adverse reactions during intubation in the observation group was significantly lower than that in the control group, with statistical significance (P < 0.05). There was no significant difference in the average time of catheterization between the two groups (P > 0.05). Conclusion The improved blind insertion technique of nasoenteric tube has a good effect in critically ill patients.