〔Abstract〕 Objective To observe and analyze the clinical effect of areola incision in the treatment of breast fibroma. Methods A total of 80 patients with breast fibroma who underwent surgical treatment in the department of mammary surgery, the first affiliated hospital of Henan University of Science and Technology from October 2018 to October 2020 were selected as the subjects of this study, and were randomly divided into the conventional group (40 cases) and the study group (40 cases) by number table method. The conventional group received conventional radial incision surgery, and the study group received areola incision surgery. The surgical situation, clinical effect, postoperative complications and clinical satisfaction of the two groups were statistically analyzed. Results In terms of incision size and hospital stay, the study group was shorter than the conventional group, but the operation time was longer than the conventional group, the difference was statistically significant (P < 0.05). In terms of total clinical response rate and treatment satisfaction, the study group (97.50%, 95.00%) was higher than the conventional group (82.5%, 77.50%), the difference was statistically significant (P < 0.05). In terms of the incidence of postoperative complications, the study group (5.00%) was lower than the conventional group (22.50%), with statistical significance (P < 0.05). Conclusion The clinical treatment of mammary fibroma through areola incision has good results, less trauma, quick postoperative recovery, fewer complications and high patient satisfaction.