〔Abstract〕 Objective To explore the application effect of wireless analgesia system in postoperative patient-controlled intravenous analgesia. Methods 200 patients who underwent thoracoscopic surgery and performed postoperative analgesia in the 900th Hospital of the Joint Service Support Force of the People's Liberation Army from January 2018 to December 2020 were selected. They were randomly divided into two groups. The traditional analgesia management group(100 cases) used conventional electronic analgesia pump for analgesia, and the wireless analgesia management group (100 cases) used wireless analgesia system for analgesia. The postoperative analgesic effect, the incidence of analgesic related adverse reactions and the process of postoperative rehabilitation were compared between the two groups. Results The visual analogue scale (VAS) score and the incidence of analgesic related adverse reactions in the wireless analgesia management group were significantly lower than the traditional analgesia management group at 2h, 6h, 12h and 24h after operation (P < 0.05). The postoperative indwelling time of drainage tube and urinary catheter in wireless analgesia management group were shorter than the traditional analgesia management group, and the time to start eating and get out of bed were earlier than the traditional analgesia management group (P < 0.05). Conclusion The application of wireless analgesia system can significantly improve the postoperative analgesic effect and shorten the postoperative rehabilitation process.