〔Abstract〕 Objective To analyze the computerized tomography (CT), Magnetic resonance imaging (MRI) performance and clinicopathological characteristics of primary central nervous system lymphoma (PCNSL) . Methods The clinical data of 60 PCNSL patients admitted to Yueyang Second People's Hospital from December 2017 to December 2018 were reviewed, and their CT, MRI performance and clinical pathological characteristics were analyzed. Results PCNSL is usually due to symptoms of intracranial hypertension, accompanied by ataxia; CT shows that there are more obvious edema bands around most of the lesions; MRI shows equal or slightly longer T2 signal, equal or slightly longer T1 The signal was uniformly enhanced after enhanced scanning, with characteristic manifestations such as fist-fist sign and gap sign; 51 cases of B-cell lymphoma and 9 cases of T-cell lymphoma were pathological features. Conclusion The specificity of the clinical manifestations of PCNSL is not obvious, but the immunohistochemical and imaging manifestations are characteristic. At the same time, it needs to be clinically distinguished from gliomas, brain metastases, and meningiomas.