〔Abstract〕 Objective To observe the clinical effect of acupuncture and moxibustion combined with Liujunzi Decoction in treating patients with functional dyspepsia of spleen-deficiency and qi-stagnation. Methods A total of 86 patients with functional dyspepsia of spleen-deficiency and qi stagnation who were admitted to Chongqing Fengjie County People’s Hospital from July 2016 to September 2017 were selected as the research objects. They were randomly divided into a control group and an observation group, with 43 cases in each group. The control group was treated with Liujunzi Decoction, and the observation group was treated with acupuncture and moxibustion based on the treatment of the control group. The course of treatment was 1 month. The treatment effect and clinical symptoms improvement time of the two groups were compared. Results After treatment, the total clinical efficiency of patients in the observation group was 97.67%, higher than 88.37%, and it was statistically significant (P < 0.05); the clinical symptom improvement time was shorter than the control group, and the difference was statistically significant (P < 0.05). Conclusion Acupuncture and Junzi Decoction were effective in the treatment of spleen deficiency.