〔Abstract〕 Objective To analyze the effect of acupuncture on intractable hiccup after stroke and its impact on the quality of life of patients. Methods 90 patients with intractable hiccup after stroke treated in Guangzhou Xinhai hospital from March 2018 to March 2020 were randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with conventional western medicine and the observation group was treated with acupuncture. The clinical efficacy, Hiccup symptom score, duration of each attack of hiccup and quality of life score were compared between the two groups. Results the total effective rate of the observation group was 95.56%, higher than 68.89% of the control group (P < 0.05); there was no significant difference in hiccup symptom scores between the two groups before treatment (P > 0.05). After treatment, the score of hiccup symptoms in the observation group was lower than that in the control group (P < 0.05); the duration of each episode of hiccup in the observation group was (1.02 ± 0.11) min, which was shorter than that in the control group (8.95 ± 0.48) min, and the difference was statistically significant (P < 0.05); there was no significant difference in the scores of quality of life between the two groups before treatment (P > 0.05). After treatment, the quality of life score of the observation group was lower than that of the control group (P < 0.05). Conclusion acupuncture can effectively reduce the number of hiccup attacks, shorten the hiccup maintenance time and improve the quality of life of patients with intractable hiccup after stroke.