〔Abstract〕 Objective Explore the effect of integrated traditional Chinese and western medicine on the treatment of limb swelling in the late stage of bone trauma. Methods A total of 108 patients with post-traumatic limb swelling admitted to Zhanjiang Second Hospital of Traditional Chinese Medicine from March 2018 to March 2019 were selected and divided into control group and observation group according to the order of drawing lots, with 54 cases in each group. The control group was given mannitol treatment, and the observation group added traditional Chinese medicine fumigation and washing on the basis of mannitol treatment to compare the treatment effects of the two groups of patients. Results After treatment, the swelling time and hospital stay of the observation group were significantly lower than those of the control group, and the difference was statistically significant (P < 0.05). Before treatment, the visual analogue scoring (VAS) scores of the two groups were not statistically different (P > 0.05); after treatment, the VAS scores of the observation group were significantly lower than those of the control group, and the difference was statistically significant (P < 0.05); Before treatment, there was no significant difference in tumor necrosis factor (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) between the two groups of patients before treatment (P > 0.05); observation group after treatment The TNF-α, CRP and IL-6 indexes of the patients were significantly lower than those of the control group, and the difference was statistically significant (P < 0.05). Conclusion The combined treatment of traditional Chinese and western medicine can effectively improve the swelling of the limbs of the patients in the later stage of bone trauma, relieve the pain of the patients, and improve the inflammatory response with significant effects.