〔Abstract〕 Objective To explore the feasibility of bubble-type nasal congestion continuous positive pressure ventilation(BNCPAP) and transnasal catheter high-flow warmed humidified positive pressure ventilation (HHFNC) in the treatment of oxygenation in children with neonatal respiratory distress syndrome (NRDS) And safety. Methods A total of 60 children with NRDS admitted to Fuzhou Second Hospital affiliated to Xiamen University from December 2019 to June 2021 were selected and divided into BNCPAP group and HHFNC group according to different ventilation modes, with 30 cases in each group. The blood gas analysis indicators, symptom improvement, and complication rate were compared between the two groups. Results The blood gas indexes of the two groups after 12h, 24h and 72h treatment were better than those before treatment (P < 0.05). The Sao2, PaO2, and oxidation index of the BNCPAP group were better than those of the HHFNC group (P < 0.05); after treatment, the observation group's non-invasive ventilation time, hospital stay, and oxygen therapy time were all compared with the control group (P > 0.05); the two groups required tracheal intubation There was no significant difference in the incidence of mechanical ventilation, bronchopulmonary dysplasia, apnea, and pulmonary air leak (P > 0.05). The incidence of nasal mucosal injury and abdominal distension in the BNCPAP group were lower than those in the HHFNC group (P < 0.05). Conclusion Compared with HHFNC, BNCPAP can improve its oxygenation function, reduce the application of mechanical ventilation for tracheal intubation, and reduce the occurrence of side effects such as abdominal distension, air leakage, and bronchopulmonary dysplasia.