〔Abstract〕 Lifestyle interventions and medical nutrition therapy (MNT) are essential for the prevention and management of type 2 diabetes mellitus (T2DM). Many evidence-based studies of diet-based lifestyle interventions provide strong evidence for weight loss and disease progression. Diet quality is important, and the quality of carbohydrates (such as refined carbohydrates and whole grain carbohydrates) is more important than the quantity. In clinical practice, dietary macronutrients including carbohydrate mass and/or restrictive effects and the combination of diet and physical activity to induce weight loss may promote T2DM remission and disease control. It is therefore recommended in the community to follow the consensus of the latest guidelines, stratified according to metabolic status, and optimize the diet for long-term maintenance of weight loss in order to achieve the prevention, treatment and remission of T2DM.