〔Abstract〕 Objective To study the nursing effect of situational health education combined with the concept of enhanced recovery after surgery (ERAS) on patients undergoing percutaneous nephrolithotomy. Methods A total of 60 PCNL patients who were admitted to Yingde People's Hospital from January 2019 to January 2021 were selected as the research objects. According to the random number table method, they were divided into observation group and control group, with 30 cases in each group. The control group was given routine care, and the observation group was treated with situational health education combined with ERAS intervention. After the intervention, the subjective feelings, various indicators during hospitalization, and the incidence of complications were compared between the two groups. Results The anxiety score, dry mouth hunger score, postoperative chills, catheter discomfort, time to get out of bed, and postoperative pain scores of the observation group were significantly lower than those of the control group, the difference was statistically significant (P < 0.05); the observation group was hospitalized The time and hospitalization expenses were significantly less than those of the control group, and the difference was statistically significant (P < 0.05); the observation group’s nursing satisfaction (96.67%) was higher than that of the control group (80.00%), and the postoperative complication rate (3.33%) Was significantly lower than the control group (20.00%), and the difference was statistically significant (P < 0.05). Conclusion Situational health education combined with ERAS nursing can significantly speed up the postoperative recovery of PCNL patients, reduce complications, shorten the length of hospitalization, and reduce patient pain and discomfort, thereby improving patient satisfaction and reducing hospitalization costs.