〔Abstract〕 Objective To investigate the effects of air pressure wave on thromboelastogram (TEG) parameters and incidence of lower extremity deep venous thrombosis (DVT) in patients with stroke. Methods 66 stroke patients admitted to Dapu County People's Hospital from August 2019 to August 2020 were selected and randomly divided into control group(n=33) and observation group(n=33). The control group was given conventional treatment, and the observation group was treated with air pressure wavetherapy instrument on this basis. The blood flow of lower limbs (leg circumference, femoral vein reflux velocity, reflux time), TEG parameters (coagulation reaction time (R), blood clot formation time (K), Angle between tangent line and horizontal line (α Angle), maximum amplitude (MA)) were compared between two groups before and after 2 weeks of treatment. The incidence of DVT was compared between the two groups after 2 weeks of treatment. Results After 2 weeks of treatment, the velocity and R value of femoral vein reflux in two groups were significantly increased compared with before treatment, and the observation group was significantly higher than the control group at the same time, the difference was statistically significant (P < 0.05). K value in two groups was significantly increased compared with before treatment, the difference was statistically significant (P < 0.05), but there was no significant difference in two groups in the same period (P > 0.05). Leg circumference diameter, reflux time, α Angle and MA values in two groups were significantly decreased compared with before treatment, and observation group was significantly lower than control group at the same time, the differences were statistically significant (P < 0.05). The incidence of DVT in observation group was significantly lower than that in control group, the difference was statistically significant (P < 0.05). Conclusion The use of air pressure wave therapy instrument for cerebral apoplexy patients has a good therapeutic effect, which is beneficial to improve the coagulation function of patients, promote the recovery of lower limb function and reduce the risk of DVT, which is beneficial to their prognosis and rehabilitation.