〔Abstract〕 Objective To explore the clinical effect of periodontal sequence treatment in the orthodontic treatment ofperiodontitis patients. Methods 85 periodontitis patients admitted to Jiangmen Stomatological Hospital from June 2017 to November 2019 were divided into controls (42) and 43) and periodontal series in orthodontic treatment, comparing total clinical efficiency, clinical attachment loss (CAL), gingival index (GI), gingival bleeding index (SBI), plaque index (PLI) and exploration depth (PD). Results The clinical treatment of the observation group was higher than the control group and the difference was significant (P <0.05) and the CAL, GI, SBI, PLI, PD index of the observation group, which was statistically significant (P <0.05). Conclusion The application of periodontal sequence therapy in the orthodontic treatment of periodontitis patients can effectively improve the treatment effect, improve their gingival bleeding and plaque, and have a positive significance to their recovery