〔Abstract〕 Objective To explore the clinical effect of ketamine propofol combined with lidocaine in pediatric surgical anesthesia. Methods 80 children who underwent surgery in Hechuan maternal and Child Health Hospital of Chongqing from January 2019 to January 2020 were randomly divided into two groups, 40 in the control group and 40 in the observation group. The control group was anesthetized with ketamine, and the observation group was anesthetized with ketamine propofol combined with lidocaine. The anesthetic effects of the two groups were compared. Results before anesthesia, there was no significant difference in heart rate and mean arterial pressure between the two groups (P > 0.05); After anesthesia, the heart rate (97.35 ± 10.34) times ·min-1 and mean arterial pressure (86.36 ± 4.29) mmHg in the observation group were lower than those in the control group (110.55 ± 9.57) times·min-1 and (98.15 ± 6.35) mmHg, the difference was statistically significant (P < 0.05). The awake time of anesthesia (19.45 ± 5.35) h and the recovery time of directional force (24.94 ± 5.02) h in the observation group were shorter than those in the control group (34.24 ± 6.77) h and (39.69 ± 6.71) h, the difference was statistically significant (P < 0.05). Conclusion Ketamine propofol combined with lidocaine can achieve more satisfactory anesthetic effect and wake up faster after operation.