〔Abstract〕 Objective To explore the effect of low-dose cinacalcet combined with paricalcitol injection in patients with refractory secondary hyperparathyroidism (SHPT) and its effect on serum PTH levels. Methods A total of 80 patients with refractory SHPT admitted to the Guangdong Provincial Agricultural Reclamation Central Hospital from February 2019 to February 2021 were selected and divided into a control group and an observation group according to the random number table method, with 40 cases in each group. The control group was treated with paricalcitol, and the observation group was treated with low-dose cinacalcet combined with paricalcitol to observe the nutritional status and parathyroid function of the two groups. Results There was no significant difference in hemoglobin (Hb) and albumin (Alb) levels between the two groups of patients before and after treatment (P > 0.05); before treatment, the levels of parathyroid hormone (iPTH), calcium, The difference in phosphorus value was not statistically significant (P > 0.05). After treatment, the iPTH, calcium, and phosphorus valuesof the observation group were lower than those of the control group, and the difference was statistically significant (P < 0.05). Conclusion Low-dose cinacalcet combined with paricalcitol injection in patients with refractory SHPT can effectively improve parathyroid function without affecting body nutrition.