〔Abstract〕 Objective To investigate the influencing factors of portal vein thrombosis (PVT) in patients with hepatitis B Cirrhosis (HBC) and the effect of anticoagulant therapy. Methods 86 patients with HBC who were treated in the First Affiliated Hospital of Henan University of Science and technology from June 2018 to June 2019 were retrospectively analyzed, the PVT group was divided into PVT group and non-PVT group, and the influencing factors of PVT and the effect of anticoagulant therapy were analyzed. Results Among 86 HBC patients, 17(19.77%) had PVT, 17(35.29%) had anticoagulant therapy, 6(35.29%) had complete recanalization, 8(47.06%) had partial recanalization, 3(17.65%) had no response The results of univariate analysis showed that there were significant differences in the history of SPLENECTOMY, Plt count and Upper gastrointestinal bleeding between the two groups (P < 0.05) , the history of SPLENECTOMY, Upper gastrointestinal bleeding history and PLT count were the risk factors of PVT in HBC patients (P < 0.05). Conclusion The history of SPLENECTOMY, Upper gastrointestinal bleeding history and high PLT count are the influencing factors of