〔Abstract〕 Objective To investigate the clinical effect of minimally invasive arthroscopic surgery on knee osteoarthritis. Methods A total of 60 patients with knee osteoarthritis admitted to The Seventh People's Hospital of Zhengzhou from January 2018 to June 2019 were selected as the study subjects. The patients were divided into control group and observation group by random number table method, with 30 patients in each group. The control group was treated with traditional surgical Methods, and the observation group was treated with arthroscopic minimally invasive surgery. The operative time, intraoperative blood loss, postoperative visual analogue scale (VAS) score, postoperative time to get out of bed for the first time, and knee Lysholm score were compared between the two groups. Results The operation time of the observation group was shorter than that of the control group, the amount of intraoperative blood loss was less than that of the control group, the postoperative VAS score was lower than that of the control group, and the time to get out of bed for the first time after surgery was shorter than that of the control group, with statistically significant differences (P < 0.05). After treatment, knee Lysholm score of 2 groups was higher than before, and knee Lysholm score of observation group was higher than control group, the difference was statistically significant (P < 0.05). Conclusion Arthroscopic minimally invasive surgery for patients with knee osteoarthritis has obvious efficacy, short operation time, less intraoperative blood loss, and light postoperative pain, and can get out of bed in a short time to move, which can fully improve the knee function of patients.