〔Abstract〕 Objective To explore the characteristics of cognitive motor development and related factors in infantile spasms (IS). Methods The data of 43 patients with IS were collected, and the characteristics of cognitive motor development and related factors were retrospectively analyzed. Results The average DQ of GDS-C energy zone was exercise (56.5 ± 21.9), individual-society (52.5 ± 21.6), hearing and language (46.4 ± 18.6), hand-eye coordination (44.9 ± 20.0), performance (42.4 ± 16.7). Multiple linear regression analysis of the age of onset and the course of the disease had statistical significance for the DQ of the GDS-C energy zone. Conclusions Infants with IS have lag in cognitive motor development. The age of onset, disease course, and frequency of attacks are related to the level of cognitive motor development.